Cutting edge

时间:2019-03-06 09:09:12166网络整理admin

By Jonathan Knight THE identification of an enzyme central to the progression of Alzheimer’s disease could speed up the design of drugs for this devastating illness. The brains of patients with Alzheimer’s tend to fill up with solid plaques of the beta amyloid protein (Ab). In healthy people, the most common form of Ab is 40 amino acids long. But in Alzheimer’s, a form of Ab with 42 amino acids is prevalent. So far, however, the secretase enzyme that snips Ab42 from a larger precursor protein has remained elusive. Now three groups in Belgium,